diagnosed-narcolepsy

People accused me of being lazy – until I was diagnosed with narcolepsy

Being diagnosed with narcolepsy proved my 'laziness' wasn't my fault

If there has been a constant in my life, it would be exhaustion. No matter how much sleep I got the night before, no matter how much coffee I drank, I was always so, so tired. In high school, I struggled to stay awake in my classes and sometimes I lost the battle altogether. It wasn’t uncommon for me to miss an entire geometry class, waking only when the bell rang. My grades suffered, and I actually failed a couple of classes. At parent-teacher conferences, most of my teachers would say that I was smart, but I didn’t apply myself. Not one mentioned that I slept in class.

I was hopeful that college would be different. Being on my own for the first time was scary, but I looked forward to the change of scenery and thought it might help me stay awake. In reality, my academic performance was worse. I still slept through some of my classes, but this time I did it in my dorm room. On more than one occasion, I managed to sleep until sometimes 4:00 in the afternoon. Needless to say, I didn’t return to school the next year.
I spent my 20s bouncing from one job to the next. Getting to work on time was an issue, since I struggled to get out of bed in the mornings. While at work, I would sometimes doze off in front of the computer, or I would struggle to concentrate on even the simplest tasks. When I worked out of town, I had trouble keeping myself awake while driving, even in the morning after a full night of sleep.

My body and mind felt starved for rest, and the constant lack of energy pulled me into depression that only made it worse. I drank heavily throughout my 20s, gained weight, and sank deeper into depression. Now that I was an adult, I no longer heard that I didn’t apply myself. Instead, I was just flat-out lazy. When I tried to describe how I felt, the usual response was to “Suck it up, everyone gets tired sometimes.”

I finally went to my doctor to get some answers. My first diagnosis was depression, which led to a frustrating month of taking an anti-depressant that did nothing for me. At my next appointment, I was diagnosed with an under active thyroid and given a prescription for Levothyroxine. A few months later and I still didn’t feel better. Feeling pretty hopeless, I gave up on doctors for a while. The end of my 20s brought huge changes to my life, and I didn’t have time to dwell on how tired I was. After my son was born, I let the exhaustion envelope me like a comfortable old blanket. Now that I had a newborn to take care of, people were more understanding when I said I was tired.

More: My autoimmune disease didn’t kill me but it took my job, friends, and house

I knew I needed to start taking care of myself to be a good mom. I found an exercise program that I loved, started going to therapy, and improved my diet. Everything should have been perfect, but I was still constantly exhausted.

My OB/GYN referred me to a primary care doctor in her network. This new doctor took her time reading over my medical history and asking me so many questions. Then she looked me in the eye and asked if I had ever been tested for narcolepsy. I’ll admit that I laughed, because it sounded so silly. I wasn’t falling asleep in the middle of conversations!

Still, she wanted me to have a sleep study. I agreed, and spent a night in a sleep study room with wires stuck to my head, face, chest, and legs. A week later, I was driving home from my son’s dentist appointment when I got a phone call about the results.

Being diagnosed with narcolepsy proved my 'laziness' wasn't my fault

Being diagnosed with narcolepsy proved my ‘laziness’ wasn’t my fault
“The test showed definite signs of narcolepsy,” she said.

I didn’t hear much after that. Shocked to finally have an answer, I actually started crying. My sweet boy was asking, “What’s wrong, mama?” from the backseat, and I couldn’t quite come up with a way to describe it. After so many years of wondering what could be wrong with me, and hearing about how lazy or unmotivated I was, I knew it wasn’t my fault.

Now that I am being treated, my life has improved drastically. For the first time in my life, I can workout every day without being completely sapped of energy. Normal daily responsibilities are no longer overwhelming. Working on my laptop isn’t a guaranteed accidental nap anymore. Best of all, I can (almost!) keep up with my energetic boy.

I do still have difficult days, but I’m thankful to finally be feeling better than I ever have

source;http://www.sheknows.com/

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10 Things I’m Really Good at Thanks to My Narcolepsy

Half length portrait of young woman from behind. Woman is wearing sunglasses and a sleeveless shirt. Subject has her hands on her hips and is looking at a city skyline. Image is landscape orientation.

Chronic headaches and narcolepsy have taught me a lot. Sleeping, staying in and modeling sweatpants are just a few of them. Thanks to my chronic illnesses, I’m really good at:

1. Sleeping

My spirit animal is a sloth. My favorite position is horizontal under my covers. And my favorite view is the one inside my eyelids.

2. Making plans and then canceling to stay in

Just because I hate doing it, doesn’t change the fact that I’m awesome at it. Sometimes I’m really really bummed that I can’t be out taking shots and dance-battling my friends on Friday nights. It’s pretty frustrating most times. However, I will admit that sometimes I’m happier with my “Friends” that show up when I turn on Netflix and my sidekick named Haagen-Dazs.

3. Collecting

I collect prescriptions, vitamins, test results and doctor business cards. I may or may not look like I run a pharmacy in my bedroom.

4. Talking

About anything — it doesn’t have to be health-related. I’m just really good at talking. But I do find myself talking in excess when explaining my chronic health issues to people who can’t relate. I’ve become really good at talking in front of groups, talking to strangers and talking when I can tell that the person listening wants me to stop. Hey, you asked, so I’m answering.

5. Showing compassion

Having endured years of chronic pain, health issues, emotional roller coaster rides, mental hardships and more, I find it really easy to feel compassion for other people and their journeys and struggles. I also just really like seeing people smile, so that’s more motivation.

6. Surprising people with my medical knowledge

With my unexpected knowledge of various medicines, methods, symptoms and diagnoses. What are the side effects of that anti-seizure medicine you ask? Oh don’t worry, I gotchu. What can I do for this kind of headache? I’m here to help! Need any OTC meds, ointments or vitamins? You’re welcome to browse my collection! But don’t worry, I promise I won’t walk in and pretend to be your doctor.

7. Enjoying time by myself

Because of how often I have to cancel plans or stay in and rest, I’ve learned how to truly enjoy and appreciate my own company. It actually kinda confuses me when people say they don’t like spending time alone. Like, I think I’m super cool, why wouldn’t I want to hangout with me?

8. Picking myself up after a fall

More often than not, I’m the only one who can get myself up again after I’ve taken a hard fall in my health journey. Everyone will fall down in life, but we only truly live when we’re getting back up again.

9. Managing pain

I don’t like to toot my own horn, but I’m pretty damn impressed by myself and my strength. Even when I’m smiling and laughing, there is some type of pain inside my skull either kicking my ass or just nagging me to pay attention to it. I have continued so many activities while enduring my worst-pain level headaches/migraines and I never know how I did it once it’s over.

10. Really enjoying life in all its beauty.

Life will never be full of only sunshine. There will be storms and we will get rained on. But each time the sun comes out, my smile gets brighter and my love for this world gets greater. Enjoying the simple things in life, putting more of my time toward seeing people who lift me up and doing more of what sets my soul on fire are all things I have seen myself get better at doing.

source;http://themighty.com

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4 Ways Narcolepsy Has Made Me A Better Parent

Mother napping with baby.

Parents are always tired, right? We are constantly walking around on the brink of sleep deprivation, especially when babies are young. If there is something mothers can bond over, it is their constant lack of sleep and wondering when their babies will finally sleep through the night.

So much about parenting, motherhood and raising kids revolves around sleep or the lack thereof. Parents live for and dream of sleep.

Imagine constantly feeling like you have gone without sleep for 48 hours. Your body aches in a futile attempt to get you to slow down. Your brain is in a chronic fog, and it’s hard to complete thoughts, much less sentences when you speak. Your mind seems to be operating in slow motion.

The restful sleep you so long for eludes you. Once you lay your head on the pillow, your mind starts to race, or sound bites from earlier in the day play in a constant loop. It can be a song lyric, a technical term, fancy words or simply someone’s name playing on repeat.

Finally, you fall asleep, but now the dreams… or are you still awake? The line between asleep and awake is blurred – and very subjective. There is no such thing as “sweet dreams” in your vocabulary. There are hallucinations and nightmares, on a good night.

That’s a brief description of what it feels like to have narcolepsy.

Parenting with a chronic condition is no easy task. As a parent with narcolepsy, I am constantly balancing taking care of myself and caring for others, and rarely have enough energy and time to do both. Most days, running out of “spoons” is unavoidable. Other times, I may have a streak of several good hours or days, maybe even decent weeks.

But even with all that said, I will go out on a limb and claim that narcolepsy has made me a better parent than I might be otherwise. Being raised by a parent with narcolepsy is teaching our four boys a number of things they otherwise wouldn’t understand, and for that I am thankful. Yes, I said it – I am thankful for my narcolepsy. Here are four reasons why I feel it makes me a better parent:

1. We don’t over-schedule our kids. Yes, it would be a logistical nightmare to balance four boys with 2 or 3 extra curricular activities. The mere thought of it makes me yawn. We try to have no more than one or two things on the schedule on any given day. Slowing down and spending more time at home than most families has created a bond between the boys like no other. They also know how to play with their toys and entertain themselves.

2. Our kids show empathy every day. The boys know I have narcolepsy with cataplexy and they understand what that means in my particular case. For example, there is something oh so tiring about reading to the kids. Some days I just doze off for a few seconds; other days I take a quick power nap. When I wake up, I know I will have a pillow shoved under my head and a blanket draped over me – and a little boy patiently holding his book, waiting for me so we can continue reading.

3. The boys are learning responsibility. There are days where I have enough energy to do homework, cook dinner and clean up afterward, but on other days I need an extra hand with setting the table or doing the dishes. The kids know to offer their help without me having to chase them down. They understand that they can’t always tell by looking at me if I am having a good day or a sleepy day.

4. We are raising four resilient boys. The kids know what to do in case I experience cataplexy while we are out in public. They know how to reach my husband on my cell phone and who they should ask for help. Our instructions to them are simple: “Keep your brothers close and safe. Direct first responders to look at my medical alert bracelet. Call Dada.”

Practicing the drill, explaining cataplexy and teaching them how to react was one of the hardest things I have had to do due to my narcolepsy. But we couldn’t afford to sugar-coat things or have them not understand exactly what was happening. They take great pride in always making sure I am doing well. They know that we as parents will always care for and protect them. But they have also learned we are only human – and in a family, we all have to protect and care for each other.

I am the first to admit that parenting with narcolepsy has its challenges. But with lots of love, empathy, patience and a good healthy sense of humor it is possible to find the good in narcolepsy. My recipe for successful parenting with narcolepsy is to take life one nap at a time

source;http://themighty.com

narcolepsy-while-driving

IS IT SIMPLE FATIGUE OR IS IT NARCOLEPSY?

We’ve all experienced times of being so tired that you just can’t keep your eyes open. For example, have you ever fallen asleep while someone was talking to you, maybe even at work? Have you ever felt so tired during the day that you had to pull off the road and take a short nap before you could continue driving?

Narcolepsy

That kind of daytime fatigue was probably the result of working late, lack of sleep or stress that interrupts quality slumber. Once you get some rest, you’re fine. But if you have narcolepsy, you can fall asleep during the day without warning. Even if you get plenty of sleep at night, you still fall asleep during daylight hours.

Narcolepsy is a chronic sleep disorder that causes overwhelming daytime drowsiness. It’s sometimes called Excessive Uncontrollable Daytime Sleepiness or just Excessive Daytime Sleepiness (EDS). No matter how you try to fight it or how many Red Bulls or triple shot lattes you drink, you can’t force yourself to stay awake.

Before being diagnosed with narcolepsy, you were likely the subject of jokes and criticism. You aren’t lazy and you aren’t faking. This is a very real medical disorder. If the condition worsens, it can interfere with your job, driving, social life and severely limit your normal activities.

Common Symptoms of Narcolepsy Are:

  1. Falling asleep one or more times during the day, even if you had plenty of sleep at night.
  2. You suddenly feel like your legs won’t support you. The feeling is one of fatigue – not fainting – and you are aware of the weakness that overcomes you.
  3. You can’t avoid falling asleep even when you’re doing things you enjoy like spending time with family and friends, participating in a sport, enjoying a hobby or attending a special event that you really wanted to attend.
  4. You may also suffer from binge eating, physical collapse while conscious, insomnia, hallucinations, or falling.

Over 200,000 people in the United States alone have been diagnosed with narcolepsy and that’s probably a much smaller number than those who are affected and don’t know what the problem is. It occurs equally in men and women, usually starting in adolescence. While there’s no medical proof that this condition is genetic, narcolepsy seems to occur in families with 8-12% having at least one close relative with this condition.

If you suffer from narcolepsy, driving a car or operating machinery can be deadly.

Falling Asleep While Driving

The way to find out if you have narcolepsy is with a sleep study and a polysomnogram. These are medical tests that are interpreted by a physician who specializes in sleep disorders. If you’re diagnosed with narcolepsy, you may be given prescription medication. You can also help yourself by making lifestyle changes, such as avoiding stressful activities or working too late before going to bed. Your doctor may recommend therapy or a support group.

Explain your condition and symptoms to family, friends and supervisor at work. You want people close to you to understand that your daytime sleepiness is not laziness, avoidance or lack of motivation but a medical problem that needs attention.

source;http://www.howyousleep.com/

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Possible Complication of Narcolepsy

Public misunderstanding of the condition

Narcolepsy may cause serious problems for you professionally and personally. Others might see you as lazy or lethargic. Your performance may suffer at school or work.

Interference with intimate relationships

Extreme sleepiness may cause low sex drive or impotence, and people with narcolepsy may even fall asleep while having sex. Intense feelings, such as anger or joy, can trigger some signs of narcolepsy such as cataplexy, causing affected people to withdraw from emotional interactions.

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Physical harm

Sleep attacks may result in physical harm to people with narcolepsy. You’re at increased risk of a car accident if you have an attack while driving. Your risk of cuts and burns is greater if you fall asleep while preparing food.

Obesity

People with narcolepsy are more likely to be overweight. The weight gain may be related to medications, inactivity, binge eating, hypocretin deficiency or a combination of factors.

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How We Treated Narcolepsy, Then vs. Now

Narcoleptics live in constant fear of sleep attacks — sudden bouts of exhaustion that can occur at any time, in any circumstance. Some sufferers of the neurological sleep disorder also experience cataplexy, episodes of muscle weakness often sparked by emotion. About one in 3,000 Americans have narcolepsy with cataplexy, and even more have the non-cataplexy variety, according to current estimates. While research has resulted in treatments to manage symptoms of the disease, and brought us closer to determining its cause, finding a cure for narcolepsy remains an uphill battle. Some aspects of our relationship with narcolepsy haven’t changed much since its 17th-century debut in the medical literature, when caffeine became the treatment du jour. Still, we’ve made considerable progress in understanding the genesis and development of the disorder. Here’s a look at how far we’ve come.

The Research

Then

The 14th-century poet Dante may have been describing himself and his own narcolepsy in “The Divine Comedy”: Throughout the work he lists the condition’s symptoms including excessive sleepiness, sudden falls and frequent napping. No wonder the guy often wrote about hell.

But it is a report by Thomas Willis, a renowned 17th century English phyisician, that is acknowledged as the first documentation of classic narcolepsy. He described sufferers as having “… a sleepy disposition — they eat and drink well, go abroad, take care well enough of their domestick (sic) affairs, yet whilst talking or walking, or eating, yea their mouthes (sic) being full of meat, they shall nod, and unless roused by others, fall fast asleep.”

Now

In the ’60s, the Stanford researcher and “father of sleep medicine” William Dement started a canine narcolepsy colony. Using narcoleptic dogs, Dement discovered the gene responsible for narcolepsy. Today, the National Institute of Neurological Disorders and Stroke (NINDS), a component of the National Institutes of Health, supports research on narcolepsy and other sleep maladies.

The Classification

Then

In the late 1800s, French physician Jean Baptiste Edouard Gélineau and German physician Carl Friedrich Otto Westphal published cases of narcolepsy, noting that sufferers exhibited daytime sleepiness and cataplexy, defined as sudden episodes of muscle weakness triggered by emotions, typically laughing or joking. Though historically associated with epilepsy, the malady was described by Gélineau as a neurosis or functional condition and named it narcolepsie from the Greek for “seized by numbness.” As an example of cataplexy, Gélineau’s patient reported collapsing at the zoo while observing monkeys.

Now

NINDS categorizes narcolepsy as a chronic brain disorder. However, it is still unknown whether narcolepsy is the same disorder with and without cataplexy.

Tired Worked_Narcolepsy

The Diagnosis

Then

In Gélineau and Westphal’s time, additional symptoms of narcolepsy included sleep paralysis, vivid dreaming, hypnagogic hallucinations, disturbed nocturnal sleep and weight gain. Daytime sleepiness, likely caused by sleep apnea or some other disorder, was often incorrectly lumped together with narcolepsy.

Now

The classic four symptoms of narcolepsy are excessive daytime sleepiness, cataplexy, hypnagogic hallucinations and sleep paralysis. However, it is often misdiagnosed as epilepsy, depression, another sleep disorder or a side effect of medication. In fact, estimates suggest that only a quarter of people who have narcolepsy have received accurate diagnoses. In one study, 60 percent of patients were misdiagnosed.

The Treatment

Then

Willis prescribed caffeine. Gélineau administered various treatments including bromides, toxic ingredients now found in pesticides, phosphates, amyl nitrate vapors, hydrotherapy, electricity and cauterization of the neck — none of which worked to prevent sleep attacks. In the early 20th Century, attempted cures involved pumping air into the sufferer’s brain or spinal cord, removing cerebrospinal fluid and administering radiation to the brain’s hypothalamic region. the 1950s first saw the use of amphetamine and Ritalin as treatments.

Now

There is no cure for narcolepsy — only medications to manage major symptoms. The cerebral stimulants modafinil and pemoline, as well as newer antidepressants that block serotonin and nonadreanaline uptake, are used to treat excessive sleepiness and cataplexy. Recently, the FDA approved GHB — yes, the popular club drug GHB — for treatment as well.

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The Cause

Then

Stories abound of head trauma as a trigger — famously in the case of Harriet Tubman, who is said to have developed narcolepsy after a two-pound weight struck her head. In their case descriptions, Gélineau and Westphal made note of hereditary causes as a potential basis for the disease. In the late 19th and early 20th centuries, doctors identified brain lesions as a main cause.

Now

Scientists have confirmed that narcolepsy is caused by the loss of the brain chemical hypocretin (aka orexin), a neurotransmitter involved in regulating the sleep-wake cycle. While it’s not clear what causes the loss of hypocretin, current research points to a combination of genetic and environmental factors that influence the immune system. The identification of hypocretin deficiency in human narcolepsy raised the possibility of new courses of treatment.

source;http://vanwinkles.com

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The Paleo Diet And Narcolepsy: What You Need To Know

steak and vegetables on a plate

The Paleo Diet—which has the hunter-gatherer food aesthetic of fruits, vegetables, and lean proteins—has gotten a whole spectrum of attention.

We’re talking everything from obsessed proponents to frantic debunkers, and all the casual snackers in-between.

Pretty much everyone has an opinion on it. Heck, even I have needlessly strong ideas on the matter.

no one cares nobody cares classic hollywood idc

But this post isn’t about me adding more commentary to the already nauseating amount of Google pages out there on the Paleo Diet.

It’s about giving you information you need, from people who’d know better than me.

In this case, that person is doctoral candidate Christina Graves, a self-proclaimed “Paleo Narco” and an active patient advocate.

Like many people, Graves was diagnosed with narcolepsy as a college student. At 20 years-old, she said goodbye to unexplained symptoms, and said hello to treatments, life-long symptom management, and the upsetting reality that her newly-named condition is still very ill-understood.

And that last one really rankled the scientist in Graves. So she dug deep into the narcolepsy literature and started looking at herself under a scientific lens.

science matt damon the martian science the shit

What she found proved interesting: a consistent correlation between what she ate and how she felt.

Since then, Graves has not only adopted a gluten-free diet, but when her narcolepsy symptoms resurfaced, she added “Paleo principles” to her dietary roster.

Of course, Graves cautions, she does all of this in combination with medication. But she does believe that her diet—along with treatment, regular exercise, and a well-established eating schedule—are the reasons she’s living with such reduced symptoms.

And I doubt she’s wrong. From diabetes to heart disease, diet has always had a proven effect on people’s health.

So what’s noteworthy isn’t that Graves changed her diet; it’s not even how she changed her diet—what’s important is will this work for you?

That’s something a whole spectrum of Google pages can’t answer for you. You’ll have to find your inner scientist and experiment.

harrison ford indiana jones scientist indiana jones and the temple of doom

If you want to start your journey to scientific self-discovery with Graves’ plan, you can find all the detail in her article “Paleo Narco: Applying Paleo Principles to Narcolepsy” and hear her go more in-depth in her talk for the Narcolepsy Network Patient Conference.

source;http://patientworthy.com/

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A real eye-opener: Narcolepsy bears classic autoimmune hallmarks

Narcoleptics suffer from bouts of sleepiness and sleep attacks, which impair their ability to function in daily life. But the precise cause of narcolepsy has long eluded scientists, and the cure for the devastating neurological disorder afflicting an estimated three million people worldwide — and one in 3,000 Americans — remains at bay.

A new study published in Pharmacological Research by the world’s leading autoimmune disease expert, Tel Aviv University’s Prof. Yehuda Shoenfeld, finds that narcolepsy bears the trademarks of a classic autoimmune disorder and should be treated accordingly. The research, led by Prof. Shoenfeld, the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at TAU’s Sackler Faculty of Medicine and Head of Zabludowicz Center for Autoimmune Diseases at Chaim Sheba Medical Center, Tel Hashomer, and conducted by doctoral student María-Teresa Arango, points to a particular autoimmune process as the trigger for the specific loss of orexin neurons, which maintain the delicate equilibrium between sleep and wakefulness in the brain.

Not just the genes

“Narcolepsy is interesting, because although it has been considered to be strictly genetic, it is induced by environmental factors, such as a burst of laughter or stress,” said Prof. Shoenfeld. “Narcolepsy is devastating to those suffering from it and debilitating to children, in particular. There is no known therapy to treat it.”

Narcolepsy first strikes people aged 10 to 25, plaguing them for life. Narcoleptics may experience any or all of the following symptoms: falling asleep without warning, anywhere, anytime, making it difficult to concentrate and fully function; excessive daytime sleepiness; the sudden loss of muscle tone; slurred speech or weakness of most muscles for a few seconds or a few minutes; a temporary inability to move or speak while falling asleep or upon waking; and hallucinations.

Prof. Shoenfeld first became interested in the subject after an avalanche of narcolepsy diagnoses swept Finland in 2009 following the administering of the H1N1 flu vaccine. “Following the H1N1 vaccine, 16 times the average incidence of narcolepsy was reported,” said Prof. Shoenfeld.

Prof. Shoenfeld discovered that a group of researchers from the Sleep Control Project at the Tokyo Metropolitan Institute of Psychiatry in Japan had published a study on an autoantibody presence attacking tribbles, small granules in our brains containing regulatory orexin neurons, which maintain the balance between sleep and wakefulness in the brain.

Fingering the culprit

“In patients and animals that develop narcolepsy, we have seen an evident depletion of orexin in the brain, and therefore a lack of balance, and later attacks of narcolepsy,” said Prof. Shoenfeld. “Why is the orexin disappearing? We think the culprit is an autoimmune reaction — the binding of autoantibodies to the tribble granules to destroy them.”

Image result for A real eye-opener: Narcolepsy bears classic autoimmune hallmarks

For the purpose of the new study, Prof. Shoenfeld and his team collaborated with the Japanese research group led by Dr. Makoto Honda to isolate the specific antibodies. These antibodies were then injected directly into laboratory mice. Ms. Arango monitored their behavior for several months, tracking their sleep patterns. “What we saw was an increased number of sleep attacks and irregular patterns of sleep in mice,” said Prof. Shoenfeld. “Mice fall asleep like dogs, circling around before going to sleep. Suddenly, in this experiment, the mice just dropped off to sleep and then, just two minutes later, woke up as though nothing had happened.

“Our hope is to change the perception and diagnosis of narcolepsy, to define it as the 81st known autoimmune disease, because a better understanding of the mechanism causing this disease, which debilitates and humiliates so many people, will lead to better treatment and, maybe one day, a cure,” Prof. Shoenfeld says. He is currently collaborating with Dr. Honda and his team to locate the area of the brain to which the targeting autoantibodies bind.

Source:http://www.sciencedaily.com

The above post is reprinted from materials provided by American Friends of Tel Aviv University

sleep-narcolepsy

Narcolepsy May Be Caused by the Immune System Attacking Brain Cells

sleep narcolepsyResearchers have found good evidence that the troubling sleep disorder narcolepsy is an autoimmune disease, in which the body’s own immune system attacks healthy brain cells. A new study published in Nature Genetics links narcolepsy to mutations of two genes involved in critical roles in protecting the body from disease. These two variations, they say, are likely conspirators against [cells that produce] hypocretin, a hormone that promotes wakefulness, and that narcoleptics have been found to lack [HealthDay News].

Narcolepsy is a disruptive disorder that can trigger “sleep attacks” without any warning during any normal activity. In addition, some people can experience “cataplexy”, where strong emotions such as anger, surprise, or laughter can trigger an instant loss of muscle strength, which, in some cases, can cause collapse [BBC News]. There is currently no cure for narcolepsy, although the symptoms can be largely controlled with a mix of stimulants and sleep-suppressing medications.

Researchers have known for years that narcoleptics are more likely to have a particular version of genes called HLA that make key immune system proteins. These proteins present small bits of invading microbes to [immune cells called] T cells, much like a handler waves a sweat-laden sock in front of a bloodhound. The proteins thus help T cells identify, track down and kill the foreign cells. In autoimmune disease, T cells may run amok, mistakenly attacking the body’s own, healthy cells [Science News]. The new study added to this knowledge by analyzing DNA from nearly 4,000 participants, all of whom had the HLA variant, but only half of whom had narcolepsy.

Lead researcher Emmanuel Mignot found that the narcoleptics in the study also had a certain variant of a gene that tells T cells–the immune cells that destroy intruders–how to react to the pathogens that HLA molecules bring them. The result indicates that T cells and HLA, which together regulate much of the body’s immune response, gang up in a unique way to destroy narcoleptics’ hypocretin cells…. The study doesn’t explain why T cells target the hypocretin cells specifically, says Mignot. It also sheds no light on what triggers the attack in the first place, a mystery for most autoimmune diseases. “We don’t know why bodies go haywire and start attacking themselves,” he says. But Mignot hopes future studies will reveal the culprit [ScienceNOW Daily News].

source;http://blogs.discovermagazine.com/

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Modafinil is pertaining the roots of narcolepsy and sleep disorders

modafinil online

Modafinil is a wonderful medication that treats sleeping disorders. It treats all the problems like sleep apnea, shift work disorders, narcolepsy etc. Modafinil in the alternative of Modafinil and is manufactured by the same pharmaceutical company. It is more popular than other medicines and is the highest selling medical product across the world. It is a multi-tasking medicine that deprives the body from sleep related problem. Modafinil 200 mg online drug treats all the problems efficiently. The main work of this tablet is to remove the negatively charged chemicals from the brain. This chemical is the main cause of sleep disorders. The order Modafinil 200 mg drug treats the below mentioned problems.

Sleep apnea:

A large chunk of folks is addicted to this problem. Sleep apnea is not a disorder but if it is ignored then it may become a worst nightmare for the person affected with this problem. People do not take accurate measures until sleep apnea intrudes in their personal lives. The sufferers can buy Modafinil 200 mg online to treat this disorder. This is the normal dosage for the patients and they can easily undertake the medication without any prescription. People can also choose the generic form of the medicine. The medicine has to be taken according to the directions of . This is to ensure the results of the drug in a hassle free manner.

Narcolepsy:

This is the most prominent reason for the development of Modafinil. According to recent studies, half of the world is facing the problem because they work for long without giving rest to their mind.  Provigil, nuvigil are some other medicines that are used in the problem of narcolepsy. However, most of people order Modafinil nowadays because it provides extra benefit in this condition. It is not a serious issue because this medicines crush the problem in few dosages. Therefore, the patients rely on the medicine for the treatment of narcolepsy.

Work shift disorder:

This problem occurs when an individual is not able to get proper sleep in night. In work shift disorder the natural mechanism of sleep turns upside down because the person feels drowsy in day and becomes active in night. The additional problems faced by the patients of work shift disorder are narcolepsy and excessive sleeping disorder. People affected from this problem can order Modafinil online medicine to keep the sleeping cycle on track. They can select the dosages according to them but in the starting period, regular consumption is necessary. It can also be taken during the working hours, as there are no drowsy effects of the drug.

Depression and anxiety:

These are counted as the causes of sleeping disorder and create many problems in the lives. It is treat these situations as well. Apart from this, other brainy problems are solved by the medicine easily. People can take the treatment of Modafinil without any prior intimation to the doctor because the drug is free from adverse issues and do not leave negative impact.

source;http://modafinilshop.wordpress.com