Male and female outpatient agoraphobic clients were compared on a range of measures of personality and psychopathology related to agoraphobia. Few sex differences emerged. Women were slightly more avoidant when alone, and men reported more concern about hurting someone when anxious. Sex-role inventory measures of masculinity were inversely related to severity of avoidance behavior and other measures of psychopathology, and sex differences on avoidance were accounted for by sex differences on masculinity. Both male and female agoraphobics were lower on masculinity than a normative sample. When response to treatment was compared, men and women showed equivalent improvement with the exception of panic frequency on which women showed a poorer outcome.